The clinical pharmacology of non-sedating antihistamines

Autor: Rob Leurs, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Manabu Tashiro, Kazuhiko Yanai, Ai Yanai
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Histamine H1 Antagonists
Non-Sedating
medicine.medical_specialty
Allergy
ATP Binding Cassette Transporter
Subfamily B
Sedation
medicine.medical_treatment
Gene Expression
Histamine H1 receptor
P-glycoprotein
law.invention
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
law
Animals
Humans
Medicine
Pharmacology (medical)
Histidine
Intensive care medicine
Adverse effect
Pharmacology
Clinical pharmacology
business.industry
Carnosine
Brain
Atopic dermatitis
medicine.disease
Doxepin
Non-sedating antihistamines
030104 developmental biology
PET
Positron-Emission Tomography
Anesthesia
Antihistamine
Genes
MDR
medicine.symptom
CNS
Impaired performance
business
030217 neurology & neurosurgery
medicine.drug
Histamine
Histamine H1 receptor occupancy
Zdroj: Yanai, K, Yoshikawa, T, Yanai, A, Nakamura, T, Iida, T, Leurs, R & Tashiro, M 2017, ' The clinical pharmacology of non-sedating antihistamines ', Pharmacology and Therapeutics, vol. 178, pp. 148-156 . https://doi.org/10.1016/j.pharmthera.2017.04.004
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2017.04.004
Popis: We previously reported on brain H1 receptor occupancy measurements of antihistamines in human brain using [11C]doxepin and positron emission tomography (PET). We proposed the use of brain H1 receptor occupancy to classify antihistamines objectively into three categories of sedating, less-sedating, and non-sedating antihistamines according to their sedative effects. Non-sedating antihistamines are recommended for the treatment of allergies such as pollinosis and atopic dermatitis because of their low penetration into the central nervous system. Physicians and pharmacists are responsible for fully educating patients about the risks of sedating antihistamines from pharmacological points of view. If a sedating antihistamine must be prescribed, its sedative effects should be thoroughly considered before choosing the drug. Non-sedating antihistamines should be preferentially used whenever possible as most antihistamines are equally efficacious, while adverse effects of sedating antihistamines can be serious. This review summarizes the pharmacological properties of clinically useful non-sedating antihistamines from the perspective of histamine function in the CNS.
Databáze: OpenAIRE
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