Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery
| Autor: | Oana Duicu, Adrian Vaduva, Danina Muntean, Rodica Lighezan, Horea Feier, Adrian Sturza, Cristian Mornos, Marian Gaspar, Adina Ionac, Raluca A. Ceausu, Claudia Borza, Lavinia Noveanu |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Monoamine Oxidase Inhibitors Monoamine oxidase Respiratory chain lcsh:Medicine Review Article Mitochondrion medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mitochondria Heart Diabetes Complications Ventricular hypertrophy Internal medicine medicine Diabetes Mellitus Humans Endothelial dysfunction Inner mitochondrial membrane Monoamine Oxidase Heart Failure General Immunology and Microbiology business.industry lcsh:R Thoracic Surgery General Medicine medicine.disease Surgery Oxidative Stress Monoamine neurotransmitter Endocrinology business Reactive Oxygen Species Oxidative stress |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2015 (2015) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Oxidative stress is a pathomechanism causally linked to the progression of chronic cardiovascular diseases and diabetes. Mitochondria have emerged as the most relevant source of reactive oxygen species, the major culprit being classically considered the respiratory chain at the inner mitochondrial membrane. In the past decade, several experimental studies unequivocally demonstrated the contribution of monoamine oxidases (MAOs) at the outer mitochondrial membrane to the maladaptative ventricular hypertrophy and endothelial dysfunction. This paper addresses the contribution of mitochondrial dysfunction to the pathogenesis of heart failure and diabetes together with the mounting evidence for an emerging role of MAO inhibition as putative cardioprotective strategy in both conditions. |
| Databáze: | OpenAIRE |
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