Tubarial gland involvement in IgG4-related diseases

Autor:	Kenichi, Takano, Makoto, Kurose, Ryuta, Kamekura, Masatoshi, Kanda, Motohisa, Yamamoto, Hiroki, Takahashi
Rok vydání:	2022
Předmět:	Otorhinolaryngology Immunoglobulin G Humans Steroids Immunoglobulin G4-Related Disease General Medicine Salivary Glands Autoimmune Diseases
Zdroj:	Acta Oto-Laryngologica. 142:616-619
ISSN:	1651-2251 0001-6489
DOI:	10.1080/00016489.2022.2104368
Popis:	Tubarial glands (TGs) are a collection of unidentified salivary glands overlying the torus tubarius in the nasopharyngeal wall. Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibroinflammatory state that often has multiple organ involvement. Involvement of the head and neck, especially the salivary glands, is common in IgG4-RD.This study aimed to elucidate the clinical significance of TGs in IgG4-RD.We investigated the local findings of TGs in ten patients with IgG4-RD.Nasopharyngeal endoscopic examination revealed oedematous swelling of the nasopharyngeal wall surrounding the TGs, which improved after steroid treatment. Moreover, sonotubometry showed a stenotic pattern in three out of seven patients with IgG4-RD.TGs may be involved in IgG4-RD. The swollen TGs may be responsible for obstructive Eustachian tube dysfunction. Further studies are required to clarify the clinical significance and physiological roles of TGs in IgG4-RD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1a25e79cb282dca4c5f56bf9fa3859 https://doi.org/10.1080/00016489.2022.2104368 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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