A novel breath test to directly measure use of vaginal gel and condoms
| Autor: | Scott Wasdo, Hartmut Derendorf, Daniel Gonzalez, Liz Montgomery, Ariane van der Straten, Donn M. Dennis, Karen Smith-McCune, Matthew M. Booth, Timothy E. Morey, Helen Cheng |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Chromatography Gas Social Psychology Anti-HIV Agents Population Organophosphonates Acetates Placebo law.invention Condoms Young Adult Pentanols Condom Randomized controlled trial law Internal medicine medicine Humans education Tenofovir Gynecology Breath test education.field_of_study medicine.diagnostic_test Vaginal microbicide business.industry Adenine Public Health Environmental and Occupational Health Vaginal gel Middle Aged Butanones Administration Intravaginal Infectious Diseases Breath Tests Cohort Vaginal Creams Foams and Jellies Female San Francisco business |
| Zdroj: | AIDS and behavior. 17(6) |
| ISSN: | 1573-3254 |
| Popis: | We assessed the feasibility of a breath test to detect women's single or concurrent use of vaginal products by adding ester taggants to vaginal gel and condom lubricant. Healthy non-pregnant women were enrolled into a two-day cohort (N = 13) and a single-day cohort (N = 12) in San Francisco. Within each cohort, women were randomized (5:1) to tagged or untagged products, and inserted in a clinical setting: 4 mL of tenofovir placebo gel (ten tagged with 15 mg 2-pentyl acetate; three untagged), and an artificial phallus with a lubricated condom (11 tagged with 15 mg 2-butyl acetate; two untagged), on two separate days (two-day cohort) or concurrently (single-day cohort). Using a portable mini-gas chromatograph, the presence/absence of taggants was determined in breath specimens collected prior to, and at timed intervals following product exposure. Demographic, clinical and product use experience data were collected by structured interview. All participants completed all visits and inserted their assigned products. At 5 min post-insertion, the breath test was 100% accurate in identifying insertion of the tagged (or untagged) gel and/or condom. The half-life in breath of the two esters tested was |
| Databáze: | OpenAIRE |
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