Comparison of biochemical and immunological biomarker levels of patients with COVID-19 with healthy individuals
| Autor: | Mehmet Emin Tekeli, Aylin Sepici Dinçel, Emel Türk Arıbaş, Canturk Kaya, Semra Tunçbilek, Ugur Ercin, Ayşe Bilgihan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Biochemistry (medical) Clinical Biochemistry Clinical course Disease Biochemistry Gastroenterology Pathogenesis Immunoassay method Internal medicine Healthy individuals medicine Biomarker (medicine) business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 46:367-375 |
| ISSN: | 1303-829X |
| Popis: | Objectives It was aimed to compare Alpha-1 antitrypsin (AAT), Alpha-1 acid glycoprotein (AGP), Total Immunoglobulin M (Total IgM), Total Immunoglobulin G (Total IgG), Galectin-3 (Gal3), and severe acute respiratory syndrome coronavirus 2 IgG (SARS-CoV-2 IgG) levels in patients with COVID-19 and healthy individuals. Methods The study included a total of 86 participants, 44 patients diagnosed with COVID-19 by real-time reverse transcription-polymerase chain reaction (rRT-PCR) test and 42 as the control group. AAT, AGP, Total IgM, and Total IgG levels were measured using the immunoturbidimetric method. Gal3 and SARS-CoV-2 IgG levels were measured using the chemiluminescent microparticle immunoassay method. Results AAT, AGP, Total IgG, Gal3, and SARS-CoV-2 IgG levels were found to be significantly higher in the patient group compared to the control group (p Conclusions High levels of AAT, AGP, Total IgG, Gal3, and SARS-CoV-2 IgG in the patient group and correlations between variables suggest that these parameters may be involved in the pathogenesis of the disease and provide an idea about the prognosis of the disease. However, new studies on this subject are needed in order to clearly reveal the laboratory tests related to the clinical course of the disease. |
| Databáze: | OpenAIRE |
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