Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia
| Autor: | Mazie J. Barcus, Priyanto Sismadi, Michael D. Edstein, Iwa Wiady, Sururi, Krisin, I. Susanti, B. Laksana, Jason D. Maguire, M. J. Bangs, Mark D. Lacy, W. Basuki, S. Tjokrosonto, J K Baird, H. Marwoto, S. Masbar |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Sulfadoxine medicine.medical_treatment Drug Resistance Disease Outbreaks Antimalarials Chloroquine Internal medicine parasitic diseases medicine Prevalence Animals Humans Treatment Failure Malaria Falciparum Child Aged biology business.industry Incidence Plasmodium falciparum Middle Aged biology.organism_classification medicine.disease Sulfadoxine/pyrimethamine Drug Combinations Infectious Diseases Pyrimethamine Parasitology Indonesia Child Preschool Tropical medicine Immunology Female business Malaria medicine.drug |
| Popis: | A recent malaria epidemic in the Menoreh Hills of Central Java has increased concern about the re-emergence of endemic malaria on Java, which threatens the island's 120 million residents. A 28-day, in-vivo test of the efficacy of treatment of malaria with antimalarial drugs was conducted among 16 7 villagers in the Menoreh Hills. The treatments investigated, chloroquine (CQ) and sulfadoxine pyrimethamine (SP), constitute, respectively, the first- and second-line treatments for uncomplicated malaria in Indonesia. The prevalence of malaria among 1389 residents screened prior to enrollment was 33%. Treatment outcomes were assessed by microscopical diagnoses, PCR-based confirmation of the diagnoses, measurement of the whole-blood concentrations of CQ and desethylchloroquine (DCQ), and identification of the Plasmodium falciparum genotypes. The 28-day cumulative incidences of therapeutic failure for CQ and SP were, respectively, 47% (N = 36) and 22% (N = 50) in the treatment of P. falciparum, and 18% (N = 77) and 67% (N = 6) in the treatment of P. vivax. Chloroquine was thus an ineffective therapy for P. falciparum malaria, and the presence of CQ-resistant P. vivax and SP-resistant P. falciparum will further compromise efforts to control resurgent malaria on Java. |
| Databáze: | OpenAIRE |
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