A clinical dilemma: estrogen replacement therapy in postmenopausal women with a background of primary breast cancer
| Autor: | R. V. Sellin, Richard L. Theriault |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Oncology
Adult congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Neoplasms Hormone-Dependent Adolescent medicine.drug_class Osteoporosis Population MEDLINE Context (language use) Breast Neoplasms Breast cancer Risk Factors Internal medicine medicine Humans skin and connective tissue diseases education education.field_of_study business.industry Surrogate endpoint Contraindications Estrogen Replacement Therapy nutritional and metabolic diseases Hematology medicine.disease Clinical trial Estrogen Female Menopause business |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 2(10) |
| ISSN: | 0923-7534 |
| Popis: | It is common practice to forego the prescribing of estrogen replacement therapy (ERT) for patients with a history of breast cancer. The consequences of estrogen deprivation particularly cardiovascular morbidity and osteoporosis are reviewed in the context of the potential risks of ERT in patients with prior breast cancer. The published data regarding breast cancer risks with oral contraceptive use and ERT in healthy women is reviewed. The rationale for a clinical trial of ERT in breast cancer patients, the proposed appropriate patient group and positive end points for assessing benefit of ERT in the population are presented. Lack of reliable clinical data makes ERT in breast cancer patients an unresolved clinical dilemma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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