Value of bimodal (18)F-choline-PET/MRI and trimodal (18)F-choline-PET/MRI/TRUS for the assessment of prostate cancer recurrence after radiation therapy and radical prostatectomy
| Autor: | Giorgio Carmignani, Andrea Romagnoli, Giuseppe Conzi, Francesco Paparo, Fabio Campodonico, Luca Cevasco, Michela Monticone, Lorenzo Bacigalupo, Gian Andrea Rollandi, Riccardo Piccazzo, Arnoldo Piccardo |
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| Rok vydání: | 2015 |
| Předmět: |
Biochemical recurrence
Male medicine.medical_specialty Fluorine Radioisotopes Urology medicine.medical_treatment Multimodal Imaging Choline Prostate cancer Image Processing Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging Diagnosis Computer-Assisted Multiparametric Magnetic Resonance Imaging Aged Neoplasm Staging Ultrasonography Aged 80 and over Prostatectomy Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Ultrasound Gastroenterology Prostatic Neoplasms Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Radiation therapy Positron emission tomography Positron-Emission Tomography Radiology Neoplasm Recurrence Local Radiopharmaceuticals business |
| Zdroj: | Abdominal imaging. 40(6) |
| ISSN: | 1432-0509 |
| Popis: | Between 27% and 53% of all patients who undergo radical prostatectomy (RP) or radiation therapy (RT) as the first-line treatment of prostate cancer (PCa) develop a biochemical recurrence. Imaging plays a pivotal role in restaging by helping to distinguish between local relapse and metastatic disease (i.e., lymph-node and skeletal metastases). At present, the most promising tools for assessing PCa patients with biochemical recurrence are multiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET)/computed tomography (CT) with radio-labeled choline derivatives. The main advantage of mpMRI is its high diagnostic accuracy in detecting local recurrence, while choline-PET/CT is able to identify lymph-node metastases when they are not suspicious on morphological imaging. The most recent advances in the field of fusion imaging have shown that multimodal co-registration, synchronized navigation, and combined interpretation are more valuable than the individual; separate assessment offered by different diagnostic techniques. The objective of the present essay was to describe the value of bimodal choline-PET/mpMRI fusion imaging and trimodal choline-PET/mpMRI/transrectal ultrasound (TRUS) in the assessment of PCa recurrence after RP and RT. Bimodal choline-PET/mpMRI fusion imaging allows morphological, functional, and metabolic information to be combined, thereby overcoming the limitations of each separate imaging modality. In addition, trimodal real-time choline-PET/mpMRI/TRUS fusion imaging may be useful for the planning and real-time guidance of biopsy procedures in order to obtain histological confirmation of the local recurrence. |
| Databáze: | OpenAIRE |
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