The effects of prior exposure to bleomycin on the incidence of pulmonary toxicities in a group of patients with disseminated testicular carcinomas
| Autor: | Archie W. Prestayko, Robert L. Comis, Stanley T. Crooke, Lawrence H. Einhorn, Joan C. D'Aoust |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Lung Diseases Male Cancer Research Pathology medicine.medical_specialty Adolescent Pulmonary toxicity Antineoplastic Agents Vinblastine Bleomycin Gastroenterology chemistry.chemical_compound Testicular Neoplasms Internal medicine medicine Humans Significant risk Neoplasm Metastasis Stage (cooking) Dose-Response Relationship Drug business.industry Incidence (epidemiology) Middle Aged Regimen Oncology chemistry Pediatrics Perinatology and Child Health Matched group Drug Therapy Combination Cisplatin business medicine.drug |
| Zdroj: | Medical and Pediatric Oncology. 5:93-98 |
| ISSN: | 1096-911X 0098-1532 |
| DOI: | 10.1002/mpo.2950050115 |
| Popis: | The incidence of pulmonary toxicities in 12 patients with prior exposure to bleomycin (BLM) was compared to the incidence of pulmonary toxicities in a matched group of 73 patients with stage III or IV testicular carcinomas treated with a regimen containing vinblastine, bleomycin, and cis-diamminedichloroplatinum. The comparison demonstrates that prior exposure to bleomycin constitutes a significant risk factor and that the risk is additive; ie, prior doses should be added to current doses to determine the cumulative dose-related probability of development of pulmonary toxicities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text