Radiation Necrosis – A Growing Problem in a Case of Brain Metastases Following Whole Brain Radiotherapy and Stereotactic Radiosurgery
| Autor: | Rovel J Colaco, Yee Pei Song |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Necrosis alk-positive adenocarcinoma medicine.medical_treatment stereotactic radiosurgery Neurosurgery Radiosurgery 03 medical and health sciences 0302 clinical medicine medicine Adenocarcinoma of the lung Anaplastic lymphoma kinase brain metastasis non-small cell lung cancer business.industry Whole brain radiotherapy General Engineering radiation necrosis Immunotherapy medicine.disease srs laser interstitial thermotherapy Radiation necrosis Oncology 030220 oncology & carcinogenesis Radiation Oncology immunotherapy Radiology medicine.symptom business 030217 neurology & neurosurgery Brain metastasis |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Stereotactic radiosurgery (SRS) provides excellent control in the treatment of brain metastases (BM). The use of newer, targeted and immunotherapy treatments have resulted in improved overall survival in patients even with an extensive metastatic disease. Hence, it is increasingly important to consider the potential for late toxicities like radiation-induced necrosis (RN) of the brain. We present a case of a patient with stage IV anaplastic lymphoma kinase (ALK) positive adenocarcinoma of the lung who underwent stereotactic radiosurgery to her brain metastases and received targeted treatment. While her intracranial and extracranial disease remained well controlled, we discuss the radiation-induced necrosis she suffered as a result of the treatment, the related diagnostic dilemma involved, and the subsequent management of this late toxicity of stereotactic radiosurgery. |
| Databáze: | OpenAIRE |
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