The Development, Physicochemical Characterisation and in Vitro Drug Release Studies of Pectinate Gel Beads Containing Thai Mango Seed Kernel Extract
| Autor: | Pimolpan Pithayanukul, Hatem Fessi, Rapepol Bavovada, Saruth Nithitanakool, Sandrine Bourgeois |
|---|---|
| Přispěvatelé: | Mahidol University [Bangkok], Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Chulalongkorn University [Bangkok] |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
enteric-coated capsule
colon-targeted delivery Pharmaceutical Science Capsules 02 engineering and technology 01 natural sciences Article Analytical Chemistry Microsphere lcsh:QD241-441 Drug Delivery Systems lcsh:Organic chemistry Drug Discovery calcium-pectinate gel beads [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Physical and Theoretical Chemistry Particle Size mango seed kernel ComputingMilieux_MISCELLANEOUS Drug Carriers Chromatography Mangifera 010405 organic chemistry Chemistry Plant Extracts ACL Organic Chemistry zinc-pectinate gel beads ionotropic gelation [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 021001 nanoscience & nanotechnology In vitro Microspheres 0104 chemical sciences Zinc Chemistry (miscellaneous) Seeds Drug release Molecular Medicine Calcium Particle size 0210 nano-technology Gels |
| Zdroj: | Molecules Molecules, MDPI, 2013, 18 (6), pp.6504-6520. ⟨10.3390/molecules18066504⟩ Molecules; Volume 18; Issue 6; Pages: 6504-6520 Molecules, Vol 18, Iss 6, Pp 6504-6520 (2013) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules18066504⟩ |
| Popis: | Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar ‘Fahlun’) were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate beads were prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentrations, and concentrations of two cross-linkers (calcium chloride and zinc acetate). The formulated beads were spherical in shape and ranged in size between 1.13 mm and 1.88 mm. Zinc-pectinate (ZPG) beads containing high amounts of MSKE showed complete entrapment efficiency (EE) of MSKE (100%), while calcium-pectinate (CPG) beads demonstrated 70% EE. The in vitro release tests indicated that MSKE-loaded CPG beads were unstable in both simulated gastric medium (SGM) and simulated intestinal medium (SIM), while MSKE-loaded ZPG beads were stable in SIM but unable to prevent the release of MSKE in SGM. The protection of ZPG beads with gastro-resistant capsules (Eudragit® L 100-55) resulted in stability in both SGM and SIM; they disintegrated immediately in simulated colonic medium containing pectinolytic enzymes. MSKE-loaded ZPG beads were stable at 4, 25 and 45 °C during the study period of four months. The present study revealed that ZPG beads in enteric-coated capsules might be a promising carrier for delivering MSKE to the colon. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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