Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors
| Autor: | Ph. Terrier, Geneviève Contesso, M. J. Terrier-Lacombe, S. Friedman, H. Mouriesse, Marc Spielmann |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Breast Sarcoma alpha 1-Antichymotrypsin Mitosis Breast Neoplasms Biology Desmin Metastasis Necrosis Breast cancer Phyllodes Tumor Biomarkers Tumor medicine Humans Neoplasm Metastasis Fibrosarcoma Survival rate Aged Retrospective Studies Phyllodes tumor Sarcoma Middle Aged Prognosis medicine.disease Immunohistochemistry Oncology alpha 1-Antitrypsin Keratins Female |
| Zdroj: | Breast Cancer Research and Treatment. 13:39-48 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/bf01806549 |
| Popis: | The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival. The series comprised 17 cystosarcomas phyllodes and 16 stromal sarcomas (excluding angiosarcomas). All tumors were reviewed and classified in similar fashion to extramammary soft tissue sarcomas. In addition, immunohistochemical studies were performed on paraffin sections with a panel of several antibodies directed against cytoskeletal filaments and cellular enzymes; five cases were also examined by electron microscopy. Most tumors were malignant fibrous histiocytoma (21 cases) and fibrosarcoma (6 cases) types. Surgery was the main therapy. Metastasis-free survival rate was significantly correlated only with histological grade, consisting of tumor differentiation, tumor necrosis, and mitotic activity. Courses and survivals of the cystosarcoma and stromal groups were identical, questioning the clinical value of this pathologic distinction. All local recurrence, metastasis, or death occurred within 30 months, though follow-up was much longer. Immunohistochemistry was disappointing for identification of specific histologic sub-types. |
| Databáze: | OpenAIRE |
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