Demethylation of the MIR145 promoter suppresses migration and invasion in breast cancer
| Autor: | Yong Li, Yu Xiang Shi, Hong Da Lu, Bo Luo, Tang Wei Wu, Zhong Xin Lu, Qing Zhi Kong, Xiaoyi Li, Shui Yi Liu, Hui Hu, Wei Qun Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Traditional medicine Cell migration Methylation Biology medicine.disease miR-145 migration and invasion 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer breast cancer Oncology ANGPT2 In vivo Cell culture 030220 oncology & carcinogenesis DNA methylation Cancer research medicine Biomarker (medicine) methylation Demethylation Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | miR-145 has been implicated in the progression of breast cancer. Here, we report that its expression is decreased in breast cancer specimens and cell lines and that this low level of expression is associated with DNA methylation of its gene, MIR145. Methylation of MIR145 has previously been correlated with cell migration and invasion, both in vivo and in vitro. We found that demethylation of MIR145 reactivates miR-145 and contributes to the anti-cancer properties of 5-aza-2'-deoxyazacytidine (5-AzaC). Therefore, miR-145 is a potentially valuable biomarker for breast cancer. |
| Databáze: | OpenAIRE |
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