Models for prediction of factor VIII half-life in severe haemophiliacs:Distinct approaches for blood group O and non-O patients
| Autor: | Peter J. Lenting, Krista Fischer, Ronan Pendu, Carina J. van Schooten, Cécile V. Denis, Karin van Dijk, H. Marijke van den Berg |
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| Přispěvatelé: | Medical Microbiology and Infection Prevention, AII - Infectious diseases, AII - Inflammatory diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities Adolescent animal diseases Hematology/Coagulation Disorders lcsh:Medicine Hemophilia A ABO Blood-Group System Cohort Studies Mice Young Adult Von Willebrand factor In vivo ABO blood group system hemic and lymphatic diseases von Willebrand Factor Blood plasma Animals Humans Medicine Platelet lcsh:Science Factor VIII Multidisciplinary biology business.industry lcsh:R Half-life Middle Aged Mice Inbred C57BL Immunology cardiovascular system biology.protein lcsh:Q Pathology/Hematology Pharmacology/Personalized Medicine business Research Article Half-Life circulatory and respiratory physiology |
| Zdroj: | Fischer, K, Pendu, R, van Schooten, C J, van Dijk, K, Denis, C V, van den Berg, H M & Lenting, P J 2009, ' Models for prediction of factor VIII half-life in severe haemophiliacs : Distinct approaches for blood group O and non-O patients ', PLoS ONE, vol. 4, no. 8, e6745 . https://doi.org/10.1371/journal.pone.0006745 PLoS ONE, Vol 4, Iss 8, p e6745 (2009) PLoS ONE, 4(8):e6745. Public Library of Science PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background: Von Willebrand factor (VWF) is critical for the in vivo survival of factor VIII (FVIII). Since FVIII half-life correlates with VWF-antigen pre-infusion levels, we hypothesized that VWF levels are useful to predict FVIII half-life. Methodology: Standardized half-life studies and analysis of pre-infusion VWF and VWF-propeptide levels were performed in a cohort of 38 patients with severe haemophilia A (FVIII |
| Databáze: | OpenAIRE |
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