Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia
| Autor: | Maria Luís Queirós, Margarida Lima, Áurea Canelhas, M. Dos Anjos Teixeira, Jorge Coutinho, Luís F. A. Bernardo, Cláudia Casais, Benvindo Justiça, A. Orfao |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes medicine.medical_specialty Systemic disease CD8-Positive T-Lymphocytes Philadelphia chromosome Polymyositis hemic and lymphatic diseases Internal medicine Acute lymphocytic leukemia medicine Humans Leukemia-Lymphoma Adult T-Cell Philadelphia Chromosome Hematology business.industry Arthritis Myeloid leukemia General Medicine medicine.disease Immunology Hypercalcemia Female Polyarthritis business CD8 |
| Zdroj: | Annals of Hematology. 81:174-177 |
| ISSN: | 1432-0584 0939-5555 |
| Popis: | Transformation of chronic myeloid leukemia (CML) often results in acute myeloblastic or, less frequently, in precursor B-cell acute lymphoblastic leukemia (ALL). T-cell blast crisis is rare. Hypercalcemia has also been described as a rare complication of CML, but this usually occurs as a terminal event. Here we report a case of a 35-year-old woman who developed a CD4(+)/CD8(+) T-cell ALL 2 years after the diagnosis of a typical Ph(+) CML. Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease. |
| Databáze: | OpenAIRE |
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