Mechanism of Anemia in Schistosoma mansoni–Infected School Children in Western Kenya
| Autor: | Sara E. Butler, W. Evan Secor, Susan P. Montgomery, Diana M. S. Karanja, Pauline M. N. Mwinzi, Erick M. O. Muok, Keziah Odhiambo |
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| Rok vydání: | 2012 |
| Předmět: |
Anemia
Cross-sectional study Enzyme-Linked Immunosorbent Assay Inflammation Virology Receptors Transferrin parasitic diseases medicine Animals Humans Schistosomiasis Child Soluble transferrin receptor biology Articles Schistosoma mansoni Odds ratio Iron deficiency medicine.disease biology.organism_classification Kenya Confidence interval Cross-Sectional Studies Infectious Diseases Social Class Immunology biology.protein Parasitology medicine.symptom |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 87:862-867 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2012.12-0248 |
| Popis: | A better understanding of the mechanism of anemia associated with Schistosoma mansoni infection might provide useful information on how treatment programs are implemented to minimize schistosomiasis-associated morbidity and maximize treatment impact. We used a cross-sectional study with serum samples from 206 Kenyan school children to determine the mechanisms in S. mansoni-associated anemia. Serum ferritin and soluble transferrin receptor levels were measured by using an enzyme-linked immunosorbent assay. Results suggest that S. mansoni-infected persons are more likely (odds ratio = 3.68, 95% confidence interval = 1.33–10.1) to have levels of serum ferritin (> 100 ng/mL) that are associated with anemia of inflammation (AI) than S. mansoni-uninfected children. Our results suggest that AI is the most common form of anemia in S. mansoni infections. In contrast, the mechanism of anemia in S. mansoni-uninfected children was iron deficiency. Moreover, the prevalence of AI in the study participants demonstrated a significant trend with S. mansoni infection intensity (P < 0.001). Our results are consistent with those observed in S. japonicum-associated anemia. |
| Databáze: | OpenAIRE |
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