Antimycobacterial immune responses in patients with pulmonary sarcoidosis
| Autor: | Detlef Kirsten, Barbara Kalsdorf, U. Greinert, Christoph Lange, Karoline Iris Gaede, Martin Ernst, C. Jafari, Robert Hörster, A. Strassburg |
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| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Tuberculosis Biopsy Enzyme-Linked Immunosorbent Assay Bronchoalveolar Lavage Statistics Nonparametric Immunophenotyping Pathogenesis Mycobacterium tuberculosis Interferon-gamma Leukocyte Count Immune system Bacterial Proteins Sarcoidosis Pulmonary Antigen medicine Humans Immunology and Allergy Interferon gamma Prospective Studies Genetics (clinical) Antigens Bacterial biology business.industry medicine.disease biology.organism_classification Immunology Sarcoidosis business medicine.drug |
| Zdroj: | The Clinical Respiratory Journal. 3:229-238 |
| ISSN: | 1752-699X 1752-6981 |
| DOI: | 10.1111/j.1752-699x.2009.00136.x |
| Popis: | Introduction: Sarcoidosis is a multisystem granulomatous disease of unknown origin. Pathogenetic involvement of Mycobacterium tuberculosis has frequently been discussed in the aetiology of sarcoidosis; however, studies still remain contradictory. Objective: We addressed the question of mycobacterial involvement in the pathogenesis of sarcoidosis by analysing cellular immune responses to mycobacterial antigens. Methods: We examined the interferon (IFN)-γ production by enzyme-linked immunospot in response to purified protein derivate (PPD) mycobacterial-specific antigen early secretory antigenic target (ESAT)-6 and culture filtrate protein (CFP)-10 by peripheral blood mononuclear cells (PBMCs) and bronchoalveolar-lavage mononuclear cells (BALMCs) of patients with pulmonary sarcoidosis, smear-negative tuberculosis and controls. Results: Release of IFN-γ in response to ex vivo contact with PPD, ESAT-6 or CFP-10 by BALMC and PBMC were comparable among patients with sarcoidosis and controls (PBMC P = 0.2326; BALMC P = 0.1767) and were less frequently observed in both groups compared to patients with tuberculosis (BALMC P |
| Databáze: | OpenAIRE |
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