Lung function and breathing patterns in hospitalised COVID-19 survivors: a review of post-COVID-19 Clinics
| Autor: | Nandan Gautum, Eyas Alhuthail, Shyam Madathil, James Stockley, Tarekegn Geberhiwot, Brendan G Cooper, Dhruv Parekh, Andrew M. Coney |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Lung Diseases Male Spirometry medicine.medical_specialty Critical Care and Emergency Medicine medicine.medical_treatment Infectious Disease Respiratory physiology Interstitial Lung Disease Structured light plethysmography Young Adult Diseases of the respiratory system Internal medicine medicine Respiratory muscle Humans Survivors Respiratory Physiology Lung Aged Aged 80 and over Mechanical ventilation medicine.diagnostic_test RC705-779 business.industry Research Interstitial lung disease COVID-19 Middle Aged medicine.disease Patient Discharge Ventilation Respiratory Function Tests Hospitalization medicine.anatomical_structure Respiratory Mechanics Breathing Cardiology Female business |
| Zdroj: | Respiratory Research, Vol 22, Iss 1, Pp 1-12 (2021) Respiratory Research |
| Popis: | Introduction There is relatively little published on the effects of COVID-19 on respiratory physiology, particularly breathing patterns. We sought to determine if there were lasting detrimental effect following hospital discharge and if these related to the severity of COVID-19. Methods We reviewed lung function and breathing patterns in COVID-19 survivors > 3 months after discharge, comparing patients who had been admitted to the intensive therapy unit (ITU) (n = 47) to those who just received ward treatments (n = 45). Lung function included spirometry and gas transfer and breathing patterns were measured with structured light plethysmography. Continuous data were compared with an independent t-test or Mann Whitney-U test (depending on distribution) and nominal data were compared using a Fisher’s exact test (for 2 categories in 2 groups) or a chi-squared test (for > 2 categories in 2 groups). A p-value of Results We found evidence of pulmonary restriction (reduced vital capacity and/or alveolar volume) in 65.4% of all patients. 36.1% of all patients has a reduced transfer factor (TLCO) but the majority of these (78.1%) had a preserved/increased transfer coefficient (KCO), suggesting an extrapulmonary cause. There were no major differences between ITU and ward lung function, although KCO alone was higher in the ITU patients (p = 0.03). This could be explained partly by obesity, respiratory muscle fatigue, localised microvascular changes, or haemosiderosis from lung damage. Abnormal breathing patterns were observed in 18.8% of subjects, although no consistent pattern of breathing pattern abnormalities was evident. Conclusions An “extrapulmonary restrictive” like pattern appears to be a common phenomenon in previously admitted COVID-19 survivors. Whilst the cause of this is not clear, the effects seem to be similar on patients whether or not they received mechanical ventilation or had ward based respiratory support/supplemental oxygen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |