Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism
| Autor: | Masahiro Mishina, Yuichi Komaba, Akira Teramoto, Takayuki Mizunari, Shiro Kobayashi, Yasuo Katayama, Shushi Kominami, Takaharu Fukuchi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Heart Diseases medicine.medical_treatment Tissue plasminogen activator Brain ischemia chemistry.chemical_compound Modified Rankin Scale Risk Factors Diabetes mellitus Fibrinolysis Edaravone medicine Humans Infusions Intravenous Aged Cerebral Hemorrhage Retrospective Studies Aged 80 and over Dose-Response Relationship Drug business.industry Thrombosis Heparin Free Radical Scavengers Middle Aged Free radical scavenger medicine.disease Prognosis Treatment Outcome chemistry Intracranial Embolism Anesthesia Surgery Female Neurology (clinical) business Antipyrine medicine.drug |
| Zdroj: | Neurologia medico-chirurgica. 48(7) |
| ISSN: | 1349-8029 |
| Popis: | Free radicals are known to activate coagulation and inhibit fibrinolysis. Edaravone, a free radical scavenger, protects vascular endothelial cells and neurons during acute brain ischemia in in vitro models. Hemorrhagic transformation and treatment outcomes were retrospectively examined in 76 patients with acute cardiogenic embolism treated with edaravone in addition to routine treatment within 24 hours of the onset of symptoms. Hemorrhagic transformation was categorized according to European Cooperative Acute Stroke Study-II. Patient characteristics were also evaluated, including evidence of hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, history of smoking, National Institutes of Health Stroke Scale on arrival, and modified Rankin scale at 3 months post-onset. Edaravone administration was one of the factors that contributed to increased frequency of hemorrhagic transformation, but had showed no significant relationship with the outcome. The present study showed that edaravone administration increased the frequency of hemorrhagic transformation with heparin in patients with cardiogenic embolism. Free radical scavenging may have promoted the coagulating conditions. Edaravone administration may allow reduction of the dose of heparin and tissue plasminogen activator in patients with acute ischemic stroke. |
| Databáze: | OpenAIRE |
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