Effect of hyperthyroidism on the transit of a caloric solid-liquid meal through the stomach, the small intestine, and the colon in man
| Autor: | J Schaffstein, B Wedmann, Martin Wegener, T Langhoff, Adamek Rj |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty Time Factors Colon Endocrinology Diabetes and Metabolism Clinical Biochemistry Hyperthyroidism Biochemistry Gastroenterology Cecum Endocrinology Internal medicine Intestine Small medicine Humans Dyspepsia Gastrointestinal Transit Aged Aged 80 and over Breath test Gastric emptying medicine.diagnostic_test business.industry Stomach digestive oral and skin physiology Biochemistry (medical) Middle Aged Small intestine Diarrhea medicine.anatomical_structure Gastric Emptying Female medicine.symptom Digestion business Hydrogen breath test |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 75:745-749 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Gastric emptying, mouth-to-cecum transit, and whole gut transit of a solid-liquid meal was measured in 20 hyperthyroid patients and in 30 control subjects by using scintigraphic techniques, the hydrogen breath test, and stool markers. In the hyperthyroid patients predefined gastrointestinal symptoms were determined and related to gastrointestinal transit. There was no significant overall difference of gastric emptying between the hyperthyroid patients and the control subjects, whereas both mouth-to-cecum transit time (mainly reflecting small intestinal transit) and whole gut transit time (mainly reflecting large intestinal transit) were significantly accelerated in hyperthyroid patients as compared to the control subjects (P less than 0.005). Mouth-to-cecum transit in hyperthyroid patients with diarrhea tended to be more rapid than in those without diarrhea (P = 0.094) and the T3 concentrations were inversely correlated with mouth-to-cecum transit time. It is concluded that in thyrotoxicosis 1) small and large intestinal transit is accelerated, while gastric emptying remains unchanged and 2) rapid intestinal transit is likely to be one factor among others implicated in the generation of diarrhea. |
| Databáze: | OpenAIRE |
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