Lithium treatment: a comparison of once-and twice-daily dosing
| Autor: | J. Waldron, J. S. Lawson, G. Abraham, James A. Owen, Nicholas J. Delva |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Bipolar Disorder Adolescent Lithium (medication) Urine Kidney Function Tests Drug Administration Schedule Leukocyte Count chemistry.chemical_compound Lithium Carbonate Humans Medicine Dosing Psychiatric Status Rating Scales Calcium metabolism Depressive Disorder business.industry Lithium carbonate Hamilton Rating Scale for Depression Middle Aged Psychiatry and Mental health Regimen chemistry Anesthesia Female medicine.symptom business Mania medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 85:65-69 |
| ISSN: | 1600-0447 0001-690X |
| DOI: | 10.1111/j.1600-0447.1992.tb01444.x |
| Popis: | The effects of once- and twice-daily dosing with lithium carbonate were compared in a non-blind, cross-over study on 20 consecutive patients with mood disorders. Mental status, side effects and target organ function were examined after a minimum of a 1-month treatment with each regimen. Eighteen patients completed the study and 2 withdrew because of side effects. There were no significant differences between the 2 groups on the Hamilton Rating Scale for Depression, the Bech-Rafaelsen Mania Scale, the UKU Side Effects Scale or in serum lithium, electrocardiogram and urine volumes. Most blood tests showed no significant difference between the 2 treatment schedules except for white blood cells, ionized calcium and phosphate concentration. The once-daily regimen was associated with a higher white cell count, increased serum phosphate and elevated serum ionized calcium. We conclude that patients are able to tolerate once-daily dosing with lithium carbonate as well as twice-daily dosing. |
| Databáze: | OpenAIRE |
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