Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhydrocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by para-tert-butyl- benzoic acid

Autor:	Lars Hareng, Paul Schuster, Volker Haake, Tilman Walk, Michael Herold, Heike Laue, Andreas Natsch
Rok vydání:	2022
Předmět:	Health Toxicology and Mutagenesis General Medicine Toxicology
Zdroj:	Archives of toxicology. 97(1)
ISSN:	1432-0738
Popis:	Molecules metabolized to para-tert-butyl-benzoic acid (p-TBBA) affect male reproduction in rats through effects on spermatogenesis. This toxicity is specific to p-TBBA and not observed in meta-substituted analogues. The underlying mode of action was evaluated by comparing effects of p-TBBA and the position isomer m-TBBA (2-50 µM) in an ex vivo 3D primary seminiferous tubule cell culture system from juvenile Sprague Dawley rats (Bio-AlteR
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa09b6599c2697994100f794c924ad99 https://pubmed.ncbi.nlm.nih.gov/36173422 Zobrazit plný text záznamu Full text from SpringerLink