Hereditary Angioedema – Consequences of a New Treatment Paradigm in Denmark

Autor: Anette Bygum
Rok vydání: 2014
Předmět:
Male
Pediatrics
Time Factors
Denmark
Tranexamic Acid/administration & dosage
C1-inhibitor
chemistry.chemical_compound
Cost of Illness
Quality of life
Icatibant
Activities of Daily Living
Hospitalisation
Angioedemas
Hereditary/diagnosis
Prospective Studies
Registries
Burden of illness
Prospective cohort study
Hereditary angioedema
biology
Bradykinin/administration & dosage
General Medicine
Middle Aged
Home Care Services
Hospitalization
Treatment Outcome
Tranexamic Acid
Cohort
Disease Progression
Female
Home therapy
Complement C1 Inhibitor Protein
Tranexamic acid
medicine.drug
Adult
medicine.medical_specialty
Dermatologic Agents/administration & dosage
Complement C1 Inhibitor Protein/administration & dosage
Dermatology
Motor Activity
Administration
Cutaneous
Bradykinin
Drug Administration Schedule
medicine
Humans
Aged
Danazol
business.industry
Angioedemas
Hereditary
Danazol/administration & dosage
medicine.disease
chemistry
Quality of Life
biology.protein
Dermatologic Agents
business
Zdroj: Bygum, A 2014, ' Hereditary Angioedema-Consequences of a New Treatment Paradigm in Denmark ', Acta Dermatovenereologica, vol. 94, no. 4, pp. 436-441 . https://doi.org/10.2340/00015555-1743
ISSN: 0001-5555
DOI: 10.2340/00015555-1743
Popis: Experiences from a Danish patient cohort with hereditary angioedema are reported with focus on home therapy and burden of illness. Eighty patients have been prospectively followed over 11 years, having experienced a total of 7,809 attacks over 469 patient years. More than half of the patients stopped long-term prophylaxis with danazol or tranexamic acid and changed treatment regimen to on-demand treatment with C1 inhibitor concentrate or icatibant. At least 10% of the attacks remained un-treated. More than half of the patients felt that hereditary angioedema had a significant psychological impact on their lives and restricted their physical activities. By December 2012, a total of 39 patients (49%) were practicing home treatment of acute attacks. Home therapy reduced the mean number of acute hospital visits by 84% and significantly improved burden of illness items. In conclusion, home therapy has profoundly improved the lives of hereditary angioedema patients.
Databáze: OpenAIRE
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