New insights into the epidemiology of ANCA-associated vasculitides in Germany: results from a claims data study
| Autor: | Philip Spearpoint, Dieter Götte, Peter Lamprecht, Matthias P. Schönermark, Ina Buchholz, Peter Rutherford, Angelika Deichmann, Bernhard Hellmich |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Prevalence Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Disease Insurance Claim Review Rheumatology Germany Epidemiology medicine Humans Pharmacology (medical) Registries Aged Retrospective Studies business.industry Incidence Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease Cohort Feasibility Studies Female Granulomatosis with polyangiitis Microscopic polyangiitis business |
| Zdroj: | Rheumatology. 60:4868-4873 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/keaa924 |
| Popis: | Objective ANCA-associated vasculitides (AAV) are rare, potentially life-threatening autoimmune diseases characterized by systemic inflammation and organ damage. AAV prevalence rates reported in Europe vary considerably and robust data sources are often lacking. This study aimed to examine the feasibility of claims data analysis as a complementary method to registry-based studies to assess the epidemiology of AAV. Methods In this retrospective observational study, anonymized longitudinal claims data from years 2013–2016 from German statutory health insurance companies (data source: InGef, Institute for Applied Health Research) have been analysed on an age- and gender-stratified cohort of ∼3 million persons representative of the German population. In this cohort, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients were identified. Results The study cohort revealed a prevalence for GPA and MPA of 210 and 46 cases per million people, respectively. The annual incidence comprised 34 GPA cases and 13 MPA cases per million people per year. Hence, 17 500 AAV patients (GPA and MPA) are estimated to live in Germany, with an annual increase of 3200 patients. According to their demographic and disease-specific characteristics, AAV patients identified in this claims data approach are representative. Conclusion This is the first study using claims data to assess the epidemiology of AAV. In Germany, AAV was diagnosed more frequently than it was estimated by previous self-reporting registry-based studies. The findings indicate that epidemiological data of AAV may have been underestimated but may also reflect improved diagnostic methods and disease recognition. |
| Databáze: | OpenAIRE |
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