Neonatal bilateral ovarian sex cord stromal tumors
| Autor: | Isabelle Flechtner, Francis Jaubert, Sabine Sarnacki, Carmen Capito, Nicolas Kalfa, Elisabeth Thibaud, Sophie Emond |
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| Rok vydání: | 2008 |
| Předmět: |
Gynecology
Ovarian Neoplasms medicine.medical_specialty Stromal cell business.industry medicine.medical_treatment Ultrasound Infant Newborn Oophorectomy Karyotype Prenatal diagnosis Hematology Clitoromegaly Oncology Pediatrics Perinatology and Child Health medicine Humans Sex Cord-Gonadal Stromal Tumors Female medicine.symptom business Testosterone Hormone |
| Zdroj: | Pediatric bloodcancer. 52(3) |
| ISSN: | 1545-5017 |
| Popis: | A child was referred for evaluation after prenatal diagnosis with macrosomia, clitoromegaly, labial hypertrophy, and a left ovarian cyst. The karyotype was 46,XX. The postnatal pelvic ultrasound was normal. High levels of anti-mullerian hormone and testosterone led to a hCG stimulation test, which was followed by isosexual precocious puberty and the appearance of a bilateral ovarian enlargement with a left tumoral mass. A left ovarian tumorectomy revealed a fibrothecoma. Six weeks later, a tumoral relapse occurred and completion of oophorectomy revealed a juvenile granulosa cell tumor (JGCT). Whereas hormonal levels decreased after surgery, a new rise associated with an enlargement of the right ovary led to the diagnosis of right JGCT. A right oophorectomy was proposed to the parents, who declined further surgery. After 2 months, the hormonal levels normalized. This case illustrates the confusing overlap between developmental and neoplastic biology in neonates. Pediatr Blood Cancer 2009;52:401–403. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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