Preconception paternal bisphenol A exposure induces sex-specific anxiety and depression behaviors in adult rats

Autor: Xianyue Zhen, Beibei Zhang, Nannan Wu, Dongliang He, Hui Zhang, Yun Zhang, Ying Fan, Chong Tian, Taibiao Li, Anne Manyande, Liangneng Zhou, Maoshu Zhu, Jian Liu, Shibin Ding, Xin Jin, Qilin Liu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Physiology
Emotions
Social Sciences
lcsh:Medicine
Anxiety
0302 clinical medicine
Pregnancy
Medicine and Health Sciences
Psychology
lcsh:Science
Depression (differential diagnoses)
Mammals
Cognitive Impairment
Multidisciplinary
Behavior
Animal
Cognitive Neurology
Depression
Eukaryota
health
Animal Models
Experimental Organism Systems
Neurology
Prenatal Exposure Delayed Effects
Vertebrates
Paternal Exposure
Female
medicine.symptom
Research Article
medicine.medical_specialty
clinical_medicine
Offspring
Cognitive Neuroscience
Affect (psychology)
Research and Analysis Methods
Rodents
03 medical and health sciences
Model Organisms
Phenols
Internal medicine
medicine
Animals
Benzhydryl Compounds
Rats
Wistar
Adverse effect
Swimming
Nutrition
Behavior
Biological Locomotion
lcsh:R
Organisms
Biology and Life Sciences
medicine.disease
Rats
Diet
030104 developmental biology
Endocrinology
Amniotes
Cognitive Science
lcsh:Q
Corticosterone
030217 neurology & neurosurgery
Behavioural despair test
Neuroscience
Zdroj: PLoS ONE, Vol 13, Iss 2, p e0192434 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Bisphenol A (BPA), an environmental endocrine-disrupting compound, has drawn a great attention for its adverse effect on behavioral development. Maternal exposure to this compound has been reported to induce anxiety and depression in offspring, but the effect of its paternal \ud exposure is rarely discussed. This study investigated whether preconception paternal BPA exposure can affect the emotions of male rats and their offspring. Eighteen adult male rats (F0) received either a vehicle or 50 μg/kg/day BPA diet for 21 weeks and were then mated with non-exposed females to produce offspring (F1). The affective behaviors of F0 and F1 rats were evaluated in the open-field test, the elevated-plus maze and the forced swimming test, and their serum corticosterone were then examined. BPA exposure induced increased anxiety behaviors along with increased serum corticosterone in F0 rats. This paternal exposure also led to increased anxiety behaviors in F1 females and aggravated depression behaviors in both sexes of F1 rats. Furthermore, only F1 females exhibited increased serum corticosterone. Overall, these data indicate that preconception paternal\ud exposure to a low dose of BPA may induce transgenerational sex-specific impairments in the affection of adult rats.
Databáze: OpenAIRE
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