Intracranial self-stimulation in mice using a modified hole-board task: Effects of d-amphetamine
| Autor: | Larry Kokkinidis, Robert M. Zacharko |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Pharmacology medicine.medical_specialty Dextroamphetamine Lateral hypothalamus Pharmacology toxicology Stimulation Mice Self Stimulation Endocrinology Internal medicine Exploratory Behavior medicine Animals Conditioning Operant Reinforcement Psychology Amphetamine Neuroscience Electrical brain stimulation medicine.drug |
| Zdroj: | Psychopharmacology. 68:169-171 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00432136 |
| Popis: | Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated reliable self-stimulation rates when given the opportunity to break a photobeam in a modified hole-board task. Self-stimulation rates were enhanced by low dosages of d-amphetamine but were depressed by high dosages. The dose-dependent effects of amphetamine could not be accounted for by changes in exploratory hole-board activity and were discussed in terms of an interaction between the rewarding properties of electrical brain stimulation and the reinforcing properties of amphetamine administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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