Relationship between Discordance of Low-Density Lipoprotein and Non-High-Density Lipoprotein Cholesterol and Risk Stratification in Acute Myocardial Infarction
| Autor: | Turgay Aslan, Kursat Akbuga, Murat Eren, Hatice Tolunay, Ozge Kurmus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Percentile Cardiovascular Diseases/complications Cholesteroç-HDL 02 engineering and technology Angina chemistry.chemical_compound Internal medicine 0202 electrical engineering electronic engineering information engineering medicine cardiovascular diseases Myocardial infarction Triglycerides business.industry Non high density lipoprotein cholesterol 020206 networking & telecommunications medicine.disease Atherosclerosis chemistry Heart failure Low-density lipoprotein Cardiology lipids (amino acids peptides and proteins) 020201 artificial intelligence & image processing Analysis of variance business Low Density Lipoprotein Receptor –Related Protein TIMI |
| Zdroj: | International Journal of Cardiovascular Sciences v.34 n.5 2021 International Journal of Cardiovascular Sciences Sociedade Brasileira de Cardiologia (SBC) instacron:SBC International Journal of Cardiovascular Sciences, Volume: 34, Issue: 5, Pages: 550-556, Published: 12 MAY 2021 |
| Popis: | Background: Sizeable proportion of patients have discordant low-density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (NHDL-C). It has been shown that discordance of LDL-C and NHDL-C either underestimates or overestimates coronary risk. Objectıve: We assessed whether this discordance has an impact on GRACE and TIMI risk scores in patients with acute myocardial infarction (AMI). Methods: We retrospectively evaluated the data of 198 consecutive patients with AMI. Fasting serum lipid profiles were recorded, GRACE and TIMI scores were calculated. Patients were divided into 3 groups according to LDL-C and NHDL-C percentiles: Discordant group: LDL-CNHDL-C (n=48). GRACE and TIMI scores, mortality and cardiovascular events (heart failure, non-fatal myocardial infarction and angina) at sixth month were compared between these three groups. Differences between these groups were analyzed with One-way ANOVA or Kruskal-Wallis rank test, and with chi-square for percentages. Also, post hoc LSD or Conover-Iman's non-parametric multiple comparison test were used. A p value NHDL-C (p=0.029 and 0.008, respectively). Cardiovascular events and mortality at sixth month were not different among groups (p=0.473 and p=0.176, respectively). Conclusion: GRACE score was higher in discordant group with LDL-C |
| Databáze: | OpenAIRE |
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