Rubella virus-associated chronic inflammation in primary immunodeficiency diseases
| Autor: | Kathleen E. Sullivan, Joseph P. Icenogle, Ludmila Perelygina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adolescent
Primary Immunodeficiency Diseases medicine.medical_treatment Immunology Inflammation Hematopoietic stem cell transplantation Vaccines Attenuated medicine.disease_cause Rubella Humans Immunology and Allergy Medicine Viral rna Child Infectious virus Granuloma business.industry Hematopoietic Stem Cell Transplantation Viral Vaccines Rubella virus Sexually Transmitted Diseases Viral medicine.disease Chronic Disease PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by Stephen Jolles and M. Teresa de la Morena Primary immunodeficiency medicine.symptom business |
| Zdroj: | Curr Opin Allergy Clin Immunol |
| ISSN: | 1473-6322 1528-4050 |
| DOI: | 10.1097/aci.0000000000000694 |
| Popis: | Purpose of the review The aim of this article is to summarize recent data on rubella virus (RuV) vaccine in chronic inflammation focusing on granulomas in individuals with primary immunodeficiencies (PIDs). Recent findings The live attenuated RuV vaccine has been recently associated with cutaneous and visceral granulomas in children with various PIDs. RuV vaccine strain can persist for decades subclinically in currently unknown body site(s) before emerging in granulomas. Histologically, RuV is predominately localized in M2 macrophages in the granuloma centers. Multiple mutations accumulate during persistence resulting in emergence of immunodeficiency-related vaccine-derived rubella viruses (iVDRVs) with altered immunological, replication, and persistence properties. Viral RNA was detected in granuloma biopsies and nasopharyngeal secretions and infectious virus were isolated from the granuloma lesions. The risk of iVDRV transmissibility to contacts needs to be evaluated. Several broad-spectrum antiviral drugs have been tested recently but did not provide significant clinical improvement. Hematopoietic stem cell transplantation remains the only reliable option for curing chronic RuV-associated granulomas in PIDs. Summary Persistence of vaccine-derived RuVs appears to be a crucial factor in a significant proportion of granulomatous disease in PIDs. RuV testing of granulomas in PID individuals might help with case management. |
| Databáze: | OpenAIRE |
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