Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
| Autor: | Robert C. Yeager, Timothy P. Gavin, L. Wiley Nifong, Robert C. Hickner, Justin A. England, Christopher B. Robinson |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Physiology medicine.medical_treatment VEGF receptors Physical Exertion Gene Expression Physical exercise chemistry.chemical_compound Physiology (medical) Internal medicine medicine Humans RNA Messenger Muscle Skeletal Messenger RNA Vascular Endothelial Growth Factor Receptor-1 biology business.industry Growth factor Skeletal muscle RNA Vascular Endothelial Growth Factor Receptor-2 Capillaries Vascular endothelial growth factor Endocrinology medicine.anatomical_structure chemistry Time course cardiovascular system biology.protein business circulatory and respiratory physiology |
| Zdroj: | Journal of Applied Physiology. 96:19-24 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00748.2003 |
| Popis: | We investigated whether acute systemic exercise increases vascular endothelial growth factor (VEGF), VEGF receptor (KDR and Flt-1) mRNA, and VEGF protein in sedentary humans. Twelve sedentary subjects were recruited and performed 1 h of acute, cycle ergometer exercise at 50% of maximal oxygen consumption. Muscle biopsies were obtained from the vastus lateralis before exercise and at 0, 2, and 4 h postexercise. Acute exercise significantly increased VEGF mRNA at 2 and 4 h and increased KDR and Flt-1 mRNA at 4 h postexercise. The sustained increase in VEGF mRNA through 4 h and the increases in KDR and Flt-1 at 4 h are different from their respective time course responses in rats. In contrast to the increase in VEGF mRNA postexercise, VEGF protein levels were decreased at 0 h postexercise. These results provide evidence in humans that 1) VEGF, KDR, and Flt-1 mRNA are increased by acute systemic exercise; 2) the time course of the VEGF, KDR, and Flt-1 mRNA responses are different from those previously reported in rats (Gavin TP and Wagner PD. Acta Physiol Scand 175: 201–209, 2002); and 3) VEGF protein is decreased immediately after exercise. |
| Databáze: | OpenAIRE |
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