| Popis: |
Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.
Graphical abstract Unlabelled Image
Highlights • Membrane contact sites (MCSs) physically and functionally link organelles. • MCSs are ubiquitous, diverse and dynamic. • Mitochondria, ER, peroxisomes, Golgi and plasma membrane all form numerous MCSs. • MCSs facilitate intracellular signalling, lipid and metabolite transfer. • MCSs are important for organelle dynamics, division and inheritance. |
Full Text from ScienceDirect 