Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses
| Autor: | Stéphane Paul, David Price, Fabienne Vernejoul, Alice Gutjahr, Eric Perouzel, Laura Papagno, Victor Appay, Alain Lamoureux, Francesco Nicoli, Bernard Verrier, Thierry Lioux, Emma Gostick, Gérard Tiraby |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Agonist medicine.drug_class Recombinant Fusion Proteins Immunology HIV Core Protein p24 Biology CD8-Positive T-Lymphocytes Inbred C57BL Ligands NO 03 medical and health sciences Mice 0302 clinical medicine Immune system Adjuvants Immunologic In vivo Immunologic medicine Immunology and Allergy Animals Antibody Formation Cell Differentiation Cytokines Dendritic Cells Membrane Glycoproteins Mice Inbred C57BL Nanoparticles Toll-Like Receptor 2 Toll-Like Receptor 7 Vaccination Immunity Cellular Immunity Humoral Adjuvants Effector Immunogenicity Immunity Humoral TLR7 Cell biology TLR2 030104 developmental biology Cellular CD8 030215 immunology |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 198(11) |
| ISSN: | 1550-6606 |
| Popis: | TLR agonists are currently being developed and tested as adjuvants in various formulations to optimize the immunogenicity and efficacy of vaccines. The aim of this study was to evaluate the immunostimulatory properties of a novel compound incorporating covalently linked moieties designed to stimulate both TLR2 and TLR7. This dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8+ T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1/TH2 profile in mice. Collectively, these data reveal the potential utility of chimeric adjuvants with synergistic activities mediated via TLRs. |
| Databáze: | OpenAIRE |
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