Current Progress in Tendon and Ligament Tissue Engineering
| Autor: | Jia Xian Law, Ling Ling Liau, Wei Lee Lim, Shiplu Roy Chowdhury, Min Hwei Ng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) Review Article 02 engineering and technology Tendons 03 medical and health sciences Tissue engineering Tensile Strength medicine Humans Musculoskeletal Diseases 030304 developmental biology Surgical repair 0303 health sciences Ligaments Tissue Engineering Tissue Scaffolds business.industry Stem Cells Body movement Stem-cell therapy musculoskeletal system Tissue Graft 020601 biomedical engineering Elasticity Surgery Tendon medicine.anatomical_structure Ligament Stem cell business Stem Cell Transplantation |
| Zdroj: | Tissue Eng Regen Med |
| ISSN: | 2212-5469 1738-2696 |
| DOI: | 10.1007/s13770-019-00196-w |
| Popis: | BACKGROUND: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and the economy. Damaged tendon and ligament can severely affect the normal body movement and might lead to many complications if not treated promptly and adequately. Current conventional treatment through surgical repair and tissue graft are ineffective with a high rate of recurrence. METHODS: In this review, we first discussed the anatomy, physiology and pathophysiology of tendon and ligament injuries and its current treatment. Secondly, we explored the current role of tendon and ligament tissue engineering, describing its recent advances. After that, we also described stem cell and cell secreted product approaches in tendon and ligament injuries. Lastly, we examined the role of the bioreactor and mechanical loading in in vitro maturation of engineered tendon and ligament. RESULTS: Tissue engineering offers various alternative ways of treatment from biological tissue constructs to stem cell therapy and cell secreted products. Bioreactor with mechanical stimulation is instrumental in preparing mature engineered tendon and ligament substitutes in vitro. CONCLUSIONS: Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament. |
| Databáze: | OpenAIRE |
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