An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs

Autor: Michael T. Longaker, Siddharth Menon, Siny Shailendra, Andrea Renda, Natalina Quarto
Přispěvatelé: Menon, Siddharth, Shailendra, Siny, Renda, Andrea, Longaker, Michael, Quarto, Natalina
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Cellular differentiation
Cell- and Tissue-Based Therapy
Gene Expression
Review
Regenerative Medicine
Regenerative medicine
Catalysi
lcsh:Chemistry
Cell therapy
Induced pluripotent stem cell
lcsh:QH301-705.5
Spectroscopy
Genetics
Computer Science Applications1707 Computer Vision and Pattern Recognition
Cell Differentiation
General Medicine
embryonic stem cells
somatic reprogramming
Cellular Reprogramming
3. Good health
Computer Science Applications
Adult Stem Cells
adult stem
Stem cell
Reprogramming
Adult stem cell
Genetic Vectors
Induced Pluripotent Stem Cells
Kruppel-Like Transcription Factors
Biology
Transfection
Catalysis
Inorganic Chemistry
Proto-Oncogene Proteins c-myc
03 medical and health sciences
Kruppel-Like Factor 4
Humans
Physical and Theoretical Chemistry
Molecular Biology
SOXB1 Transcription Factors
Organic Chemistry
Embryonic stem cell
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
induced pluripotent stem cells (iPSCs)
Neuroscience
Octamer Transcription Factor-3
Biomarkers
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 1, p 141 (2016)
ISSN: 1422-0067
Popis: Stem cells are classified into embryonic stem cells and adult stem cells. An evolving alternative to conventional stem cell therapies is induced pluripotent stem cells (iPSCs), which have a multi-lineage potential comparable to conventionally acquired embryonic stem cells with the additional benefits of being less immunoreactive and avoiding many of the ethical concerns raised with the use of embryonic material. The ability to generate iPSCs from somatic cells provides tremendous promise for regenerative medicine. The breakthrough of iPSCs has raised the possibility that patient-specific iPSCs can provide autologous cells for cell therapy without the concern for immune rejection. iPSCs are also relevant tools for modeling human diseases and drugs screening. However, there are still several hurdles to overcome before iPSCs can be used for translational purposes. Here, we review the recent advances in somatic reprogramming and the challenges that must be overcome to move this strategy closer to clinical application.
Databáze: OpenAIRE
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