Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa
| Autor: | BC Anisiuba, Kei Asayama, B A Ezeala-Adikaibe, Chinwuba K. Ijoma, Ifeoma Ulasi, Daniel Lemogoum, J R M'Buyamba-Kabangu, Augustine N. Odili, Jan A. Staessen, Yan-Ping Liu, Lutgarde Thijs, Joseph Kaptue, Marius K. Kamdem |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Sub saharan Hemodynamics Specialties of internal medicine Internal medicine Heart rate medicine Diseases of the circulatory (Cardiovascular) system Pulse wave velocity business.industry Prevention Black Africans Augmentation index General Medicine medicine.disease Arterial stiffness Surgery Blood pressure RC581-951 RC666-701 Cardiology business Body mass index |
| Zdroj: | Artery Research, Vol 6, Iss 1 (2011) |
| ISSN: | 1876-4401 |
| Popis: | Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions. Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting native African patients to compare the efficacy of various antihypertensive drugs given once daily as single-pill combinations. Two centres engaged in pulse wave analysis and measured carotid–femoral pulse wave velocity (PWV). Statistical methods included single and multiple linear regressions. Results: Of 172 patients screened, 116 entered the ancillary study on central haemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1mmHg). The augmentation indexes were higher (p0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV. Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations highlight the potential for the prevention of irreversible arterial damage by timely treating sub-Saharan hypertensive patients to target blood pressure levels. |
| Databáze: | OpenAIRE |
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