Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women

Autor: Vera Regitz-Zagrosek, Anna Brecht, Ute Seeland, Sabine Oertelt-Prigione, Mirjam Ruecke, Ahmad T. Nauman, Verena Stangl, Fabian Knebel
Jazyk: angličtina
Rok vydání: 2016
Předmět:
030204 cardiovascular system & hematology
600 Technik
Medizin
angewandte Wissenschaften::610 Medizin und Gesundheit
augmentation index
Biochemistry
0302 clinical medicine
Risk Factors
Germany
Medicine
030212 general & internal medicine
Pulse wave velocity
Aorta
Subclinical infection
education.field_of_study
vascular dysfunction
Middle Aged
Original Papers
arterial stiffness
Cardiovascular Diseases
Cardiology
cardiovascular system
Female
Cardiomyopathies
circulatory and respiratory physiology
Adult
medicine.medical_specialty
Waist
pulse wave velocity
Population
Biophysics
Diastole
Pulse Wave Analysis
vascular phenotypes
03 medical and health sciences
Vascular Stiffness
Internal medicine
Humans
cardiovascular diseases
education
Molecular Biology
Pathological
Aged
Original Paper
Risk Management
business.industry
Myocardium
Cell Biology
medicine.disease
Cross-Sectional Studies
Arterial stiffness
diastolic dysfunction
business
Blood sampling
Zdroj: Bioscience Reports
ISSN: 1573-4935
0144-8463
Popis: The present study reports markers of vascular function among a general female population and shows that left ventricular diastolic dysfunction (LVDD) is significantly associated with pathological PWV (⩾9.7 m/s), a waist circumference >80 cm and age.
The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional study recruited 965 women aged 25–75 years from 12 districts of Berlin. The ASt indices, brachial AIx, aortic PWV and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup (n=343) was examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic mitral annulus velocity (é) were assessed. Questionnaires, medical history and blood sampling were used for the evaluation of individual risk factors. Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas 17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI: 1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm [OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high prevalence of markers for vascular dysfunction and ASt in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular-risk assessment in particular to identify subclinical myocardial diastolic dysfunction.
Databáze: OpenAIRE
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