Neuroleptic Malignant Syndrome in an Adolescent Receiving Olanzapine-Lithium Combination Therapy
| Autor: | Neeraj Berry, Sapna Pradhan, Rajesh Sagar, Suresh Kumar Gupta |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Olanzapine Pediatrics medicine.medical_specialty Bipolar Disorder Adolescent Combination therapy medicine.medical_treatment Lithium Diagnosis Differential Benzodiazepines medicine Humans Neuroleptic Malignant Syndrome Pharmacology (medical) Leukocytosis Antipsychotic Chemotherapy biology business.industry Pirenzepine medicine.disease Neuroleptic malignant syndrome Concomitant Anesthesia biology.protein Drug Therapy Combination Creatine kinase medicine.symptom business Antipsychotic Agents medicine.drug |
| Zdroj: | Pharmacotherapy. 23:255-259 |
| ISSN: | 0277-0008 |
| Popis: | A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. When both drugs were discontinued, his fever and rigidity subsided and biochemical irregularities spontaneously returned to normal, without any complications. Classic neuroleptic malignant syndrome (NMS) was diagnosed. Concomitant administration of lithium with olanzapine may place patients at risk for NMS. Clinicians need to be aware of this rare but potentially fatal side effect in patients of all ages, and especially in adolescents receiving both drugs. |
| Databáze: | OpenAIRE |
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