Effects of chronic nicotine and haloperidol administration on muscarinic receptor-mediated phosphoinositide turnover in rat brain slices
Autor: | Richard Jed Wyatt, Lauren L. Wing, Rena Li, De-Maw Chuang, Darrell G. Kirch |
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Rok vydání: | 1992 |
Předmět: |
Male
Nicotine medicine.medical_specialty Haloperidol Decanoate Hippocampus Striatum In Vitro Techniques Phosphatidylinositols Rats Sprague-Dawley Internal medicine Muscarinic acetylcholine receptor medicine Haloperidol Animals Brain Chemistry Pharmacology Chemistry Dopaminergic Receptors Muscarinic Frontal Lobe Rats Neostriatum Endocrinology Cholinergic Carbachol medicine.drug |
Zdroj: | Psychopharmacology. 109:248-250 |
ISSN: | 1432-2072 0033-3158 |
Popis: | Muscarinic receptor-mediated phosphoinositide (PI) turnover in rat brain slices was assessed after chronic administration of nicotine (12 mg/kg/day) or haloperidol decanoate (1.5 mg/kg/day), either alone or in combination, for 6 weeks. Nicotine alone did not significantly alter carbachol-induced inositol monophosphate (IP1) accumulation in the frontal cortex, but did result in a significant increase in the hippocampus, and in a decrease in the striatum. Haloperidol alone attenuated carbachol-stimulated IP1 accumulation in all three brain regions. Chronic treatment with combined nicotine and haloperidol resulted in no significant change in carbachol-sensitive IP1 accumulation in either the frontal cortex or hippocampus but did result in a decrease in the striatum. The results suggest significant cross-talk between cholinergic and dopaminergic systems in affecting PI metabolism. |
Databáze: | OpenAIRE |
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