Inhibition of HSV-1 attachment, entry, and cell-to-cell spread by functionalized multivalent gold nanoparticles
| Autor: | Ronit Sarid, Dana Baram-Pinto, Sourabh Shukla, Aharon Gedanken |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Cell Nanoparticle medicine.disease_cause Antiviral Agents Virus Biomaterials chemistry.chemical_compound Cell Movement Chlorocebus aethiops Materials Testing medicine Cell Adhesion Animals General Materials Science Vero Cells Mesna Drug Carriers General Chemistry Heparan sulfate Ligand (biochemistry) Virology medicine.anatomical_structure Herpes simplex virus chemistry Colloidal gold Vero cell Biophysics Nanoparticles Virus Inactivation Gold Biotechnology |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany). 6(9) |
| ISSN: | 1613-6829 |
| Popis: | The use of modified nanoparticles in interactions with biological targets is attracting rapidly increasing attention. In this Full Paper, the application of gold nanoparticles capped with mercaptoethanesulfonate (Au-MES NPs) as effective inhibitors of Herpes simplex virus type 1 infection based on their ability to mimic cell-surface-receptor heparan sulfate is described. Mechanistic studies reveal that Au-MES NPs interfere with viral attachment, entry, and cell-to-cell spread, thereby preventing subsequent viral infection in a multimodal manner. The ligand multiplicity achieved with carrier nanoparticles is crucial in generating polyvalent interactions with the virus at high specificity, strength, and efficiency. Such multivalent-nanoparticle-mediated inhibition is a promising approach for alternative antiviral therapy. |
| Databáze: | OpenAIRE |
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