Impact of the Di(2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats

Autor: Muslum Gok, Nurhayat Barlas, Gözde Karabulut, Duygu Aydemir, Gulsu Simsek, Nuriye Nuray Ulusu
Rok vydání: 2017
Předmět:
0301 basic medicine
endocrine system
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Sodium
Clinical Biochemistry
Glutathione reductase
Developmental toxicity
chemistry.chemical_element
010501 environmental sciences
Calcium
Glucosephosphate Dehydrogenase
Kidney
01 natural sciences
Biochemistry
Liver and kidney histology
Serum biochemical parameters
Inorganic Chemistry
03 medical and health sciences
chemistry.chemical_compound
Selenium
Plasticizers
Internal medicine
Diethylhexyl Phthalate
medicine
Animals
Rats
Wistar
0105 earth and related environmental sciences
Glutathione Transferase
Minerals
Phosphogluconate Dehydrogenase
Biochemistry (medical)
Phthalate
Di-(2-ethylhexyl) phthalate
General Medicine
Glutathione
Organ Size
Trace Elements
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Glutathione Reductase
chemistry
Liver
Glutathione metabolism enzymes
Trace elements and minerals
Zdroj: Biological trace element research. 186(2)
ISSN: 1559-0720
Popis: Di(2-ethylhexyl) phthalate (DEHP) is a widely used synthetic polymer in the industry. DEHP may induce reproductive and developmental toxicity, obesity, carcinogenesis and cause abnormal endocrine function in both human and wildlife. The aim of this study was to investigate trace element and mineral levels in relation of kidney and liver damage in DEHP-administered rats. Therefore, prepubertal male rats were dosed with 0, 100, 200, and 400 mg/kg/day of DEHP. At the end of the experiment, trace element and mineral levels, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR) and glutathione S-transferase (GST) enzyme activities were evaluated in the serum, liver, and kidney samples of rats. Furthermore, serum clinical biochemistry parameters, organ/body weight ratios and histological changes were investigated to evaluate impact of DEHP more detailed. Our data indicated that sodium (Na), calcium (Ca), potassium (K), lithium (Li), rubidium (Rb) and cesium (Cs) levels significantly decreased, however iron (Fe) and selenium (Se) concentrations significantly increased in DEHP-administered groups compared to the control in the serum samples. On the other hand, upon DEHP administration, selenium concentration, G6PD and GR activities were significantly elevated, however 6-PGD activity significantly decreased compared to the control group in the kidney samples. Decreased G6PD activity was the only significant change between anti-oxidant enzyme activities in the liver samples. Upon DEHP administration, aberrant serum biochemical parameters have arisen and abnormal histological changes were observed in the kidney and liver tissue. In conclusion, DEHP may induce liver and kidney damage, also result abnormalities in the trace element and mineral levels. © Springer Science+Business Media, LLC, part of Springer Nature 2018.
Databáze: OpenAIRE
Externí odkaz: