Angiopeptin enhances acetylcholine-induced relaxation and inhibits intimal hyperplasia after vascular injury
| Autor: | David H. Coy, Dennis B. McNamara, Jerry T. Light, I-Li Chen, L. L. Longenecker, P. J. Kadowitz, William A. Murphy, J. A. Bellan |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Intimal hyperplasia Physiology Prostaglandin Peptides Cyclic Catheterization chemistry.chemical_compound Physiology (medical) medicine.artery Internal medicine medicine Animals Aorta Lagomorpha Arachidonic Acid biology business.industry Endothelium-derived relaxing factor Balloon catheter Drug Synergism Hyperplasia biology.organism_classification medicine.disease Acetylcholine Vasodilation Endocrinology Somatostatin chemistry Microscopy Electron Scanning Eicosanoids Rabbits Cardiology and Cardiovascular Medicine business Tunica Intima Oligopeptides |
| Zdroj: | The American journal of physiology. 265(4 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | The effects of the somatostatin analogue, angiopeptin (BIM-23014), on neoendothelial function, as evidenced by formation of prostaglandin (PG) I2 and by acetylcholine-induced relaxation (formation of endothelial-derived relaxing factor), were investigated in the rabbit aorta. A balloon catheter injury of the thoracic and abdominal aorta was induced in New Zealand White rabbits. Animals treated with angiopeptin for 2 or 4 wk were compared with untreated rabbits at 2 or 4 wk after the induction of injury, as well as to sham-operated controls. When the rabbits were killed, vascular rings were assessed for arachidonic acid-stimulated PGI2 formation, acetylcholine-induced relaxation, and the degree of intimal hyperplasia. Vascular rings from animals treated with angiopeptin exhibited enhanced acetylcholine-induced relaxation; however, angiopeptin treatment had no effect on arachidonic acid-stimulated PGI2 formation. Intimal hyperplasia in treated animals was reduced by 36%. Treatment with another somatostatin analogue, BIM-23030, did not enhance relaxation or inhibit intimal hyperplasia. These data suggest that treatment with angiopeptin may inhibit intimal hyperplasia in part by its beneficial effect on neoendothelial function. |
| Databáze: | OpenAIRE |
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