Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability

Autor:	Siyan Zhu, Jiancheng Huang, Rong Xu, Yekai Wang, Yiming Wan, Rachel McNeel, Edward Parker, Douglas Kolson, Michelle Yam, Bradley Webb, Chen Zhao, Jenna Sigado, Jianhai Du
Rok vydání:	2022
Předmět:	Male Isocitrates Citric Acid Cycle Retinal Degeneration Cell Biology NAD Biochemistry Isocitrate Dehydrogenase Mice Semen Animals Humans Ketoglutaric Acids Spermatogenesis Molecular Biology Infertility Male
Zdroj:	Journal of Biological Chemistry. 298:102387
ISSN:	0021-9258
DOI:	10.1016/j.jbc.2022.102387
Popis:	Isocitrate dehydrogenase 3 (IDH3) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate and concurrently converts NAD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f09048270b22c37af97ca347b8baf7 https://doi.org/10.1016/j.jbc.2022.102387 Zobrazit plný text záznamu