In Vitro Responses of Human Peripheral Small Arteries in Hypercholesterolemia and Effects of Therapy
| Autor: | Anthony M. Heagerty, Grahame K. Goode |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty Endothelium Thromboxane Lipoproteins Hypercholesterolemia Blood lipids Blood Pressure In Vitro Techniques Arginine Norepinephrine Thromboxane A2 chemistry.chemical_compound Physiology (medical) Internal medicine medicine Humans business.industry Cholesterol Arteries Middle Aged medicine.disease Prostaglandin Endoperoxides Synthetic Blood pressure Endocrinology medicine.anatomical_structure Atheroma chemistry Vasoconstriction 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Female medicine.symptom Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Circulation. 91:2898-2903 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.91.12.2898 |
| Popis: | Background Studies in both animals and humans with raised lipid levels have demonstrated abnormalities in vascular function usually manifested by an impairment in endothelium-dependent vasorelaxation. This is believed to be an early event in atheroma formation. There are few data on the effects on vascular function in humans of lowering serum lipids. We conducted a study to investigate the effects of cholesterol reduction on the in vitro function of human peripheral small arteries in middle-aged patients with hypercholesterolemia. Methods and Results Subcutaneous gluteal fat biopsies were taken from 18 hypercholesterolemic (HC) patients (mean±SEM serum total cholesterol, 9.7±0.57 mmol/L) and 16 age- and sex-matched control subjects (mean cholesterol, 4.69±0.18 mmol/L). Subcutaneous small arteries (internal diameter, −9 to 10 −6 mol/L) after preconstriction with the thromboxane A 2 analogue U46619 (10 −6 mol/L, mean maximum relaxation, 42.9±5.4%) compared with control subjects (85.7±4.0%, P l -arginine (3 mmol/L) improved the endothelium-dependent vasorelaxation response to acetylcholine (70.9±6.0%, P −9 to 10 −6 mol/L) between the HC group (mean maximum relaxation, 76.9±6.0%) and the control subjects (89.7±6%; P P P P P P P Conclusions These results demonstrate abnormalities of both endothelium-dependent and -independent relaxation in human peripheral small arteries that are normalized with effective lipid lowering. The changes in blood pressure may have been secondary to the improvement in vascular function. |
| Databáze: | OpenAIRE |
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