Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material
| Autor: | Fauzan Amin, Ika Agustia Umami, Boima Situmeang, Micha Mahardika, Agus Malik Ibrahim |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Jurnal Pendidikan Kimia (JPKim); Vol 13, No 1 (2021): April; 1-9 |
| ISSN: | 2549-3116 2085-3653 |
| DOI: | 10.24114/jpkim.v13i1.24138 |
| Popis: | Drug delivery system is a system that describes the journey of a drug to its target location. The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%; 266,7%; 303.3%; 586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes. Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, Seaweed |
| Databáze: | OpenAIRE |
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