Exploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
| Autor: | Jeanne Neuffer, Raúl González-Domínguez, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Bénédicte Driollet, Catherine Helmer, Andrea Du Preez, Chiara de Lucia, Silvie R. Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Sandrine Thuret, Claudine Manach, Mercè Pallàs, Mireia Urpi-Sardà, Alex Sánchez-Pla, Cristina Andres-Lacueva, Cécilia Samieri |
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| Přispěvatelé: | Structural and Functional Plasticity of the nervous system (SILS, FNWI), Paediatrics |
| Rok vydání: | 2022 |
| Předmět: |
Aging
propionic acid Epidemiology Cellular and Molecular Neuroscience Developmental Neuroscience Envelliment Brain-Gut Axis Humans Metabolomics Cognitive Dysfunction gut–brain axis Aged gut microbiota metabolomics cognitive decline Alzheimer’s disease dementia Aged 80 and over Nutrition and Dietetics Microbiota Health Policy Psychiatry and Mental health Case-Control Studies Neurology (clinical) Geriatrics and Gerontology Food Science |
| Zdroj: | Nutrients, 14(21):4688. Multidisciplinary Digital Publishing Institute (MDPI) Nutrients; Volume 14; Issue 21; Pages: 4688 |
| ISSN: | 2072-6643 |
| Popis: | The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterations linked to cognitive aging, likely due to limitations in metabolite coverage or follow-ups. Older persons from the Three-City population-based cohort who had not been diagnosed with dementia at the time of blood sampling were included, and repeated measures of cognition over 12 subsequent years were collected. Using a targeted metabolomics platform, we identified 72 circulating gut-derived metabolites in a case–control study on cognitive decline, nested within the cohort (discovery n = 418; validation n = 420). Higher serum levels of propionic acid, a short-chain fatty acid, were associated with increased odds of cognitive decline (OR for 1 SD = 1.40 (95% CI 1.11, 1.75) for discovery and 1.26 (1.02, 1.55) for validation). Additional analyses suggested mediation by hypercholesterolemia and diabetes. Propionic acid strongly correlated with blood glucose (r = 0.79) and with intakes of meat and cheese (r > 0.15), but not fiber (r = 0.04), suggesting a minor role of prebiotic foods per se, but a possible link to processed foods, in which propionic acid is a common preservative. The adverse impact of propionic acid on metabolism and cognition deserves further investigation. |
| Databáze: | OpenAIRE |
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