Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects
| Autor: | Lijuan Yuan, Guoqiang Bao, Xianli He, Liu Ziyu, Xi E Hu, Falin Qu, Gang Wei, Jianguo Lu, Ping Yang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
gastric cancer prognosis medicine.medical_specialty MTRR MTR folate metabolism Single-nucleotide polymorphism Gastroenterology polymorphism 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype medicine SNP Methionine synthase biology Proportional hazards model business.industry (Methionine synthase) reductase 030104 developmental biology Oncology 030220 oncology & carcinogenesis Methylenetetrahydrofolate reductase MTHFR biology.protein business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.46978 |
| Popis: | Influence of folate metabolism has long been studied in cancer and copies evidences have suggested that the key genes involved were correlated with GC risk and prognosis. However, their genetically association and contribution for GC prognosis are still elusive. To evaluate the effect of folate metabolism related genes polymorphisms on the prognosis of gastric cancer (GC), the genotype of seven single nucleotide polymorphisms (SNPs) of three genes were selected and genotyped in a cohort of 664 GC patients, including genes of Methylenetetrahydrofolate reductase (MTHFR), Methionine synthase reductase (MTRR), and Methionine synthase (MTR). Kaplan-Meier Curve, long-rank tests and multivariate Cox proportional hazard model were used for prognosis analysis. The results demonstrated that TT or CT/TT genotypes of SNP rs1532268 in MTRR gene coding region are significantly associated with a poorer overall survival (OS) when compared with CC genotype (HR=2.340, 95% CI: 1.240-4.414, p=0.009; or HR=1.502, 95% CI: 1.083-2.085, p=0.015, respectively). Furthermore, comparing to that of the CC genotype, the detrimental effect of rs1532268 TT genotype was also evident in the special subgroups of GC patients, especially in patients with BMI |
| Databáze: | OpenAIRE |
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