Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32
| Autor: | Lin, M. -W, Curtis, D., Williams, N., Arranz, M., Nanko, S., Collier, D., Mcguffin, P., robin murray, Owen, M., Gill, M., Powell, J. |
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| Rok vydání: | 1995 |
| Předmět: |
Genetic Markers
Male Linkage disequilibrium Genetic Linkage Schizophrenia (object-oriented programming) Biology Polymerase Chain Reaction Linkage Disequilibrium Genetic linkage mental disorders Adoption Genetics Diseases in Twins Humans Family Gene Biological Psychiatry Genetics (clinical) Chromosome 13 Linkage (software) Sex Characteristics Polymorphism Genetic Chromosomes Human Pair 13 Chromosome Chromosome Mapping Pedigree Psychiatry and Mental health Phenotype Genetic marker Schizophrenia Female Lod Score |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0955-8829 |
| Popis: | Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at theta = 0 and alpha of 0.5 and nearby markers also produced positive values. |
| Databáze: | OpenAIRE |
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