Secretion of Calcitonin Gene-Related Peptide from Baby Rat Thyroid Glands in Vitro
| Autor: | Susan A. Borosky, Cary W. Cooper, Tai-Chan Peng |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Calcitonin
chemistry.chemical_classification medicine.medical_specialty Chemistry Calcitonin Gene-Related Peptide Thyroid Thyroid Gland Nerve Tissue Proteins Peptide Radioimmunoassay Calcitonin gene-related peptide General Biochemistry Genetics and Molecular Biology In vitro Rats Rat Thyroid medicine.anatomical_structure Endocrinology Animals Newborn Internal medicine medicine Animals Secretion |
| Zdroj: | Experimental Biology and Medicine. 180:562-566 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Thyroid glands from 8-day-old rat pups were incubated in serum-free medium for 6 hr. Both calcitonin (CT) and calcitonin gene-related peptide (CGRP) released into medium were measured by radioimmunoassay. In 6 separate experiments CGRP was easily detected in medium in ng/ml concentrations. In 4 of the 6 experiments, where CT release was stimulated by high medium [Ca], the concentration of CGRP in medium showed a positive, significant correlation with the medium CT concentration (r = 0.41-0.69, p less than .05- less than .01). The results are in concert with reports describing the presence of CGRP in the C-cell, and they further show that CGRP, as well as CT, can be secreted by C-cell. |
| Databáze: | OpenAIRE |
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