Inflammation and cardiovascular events in individuals with and without chronic kidney disease
| Autor: | Essam F. Elsayed, Daniel E. Weiner, Mark J. Sarnak, Deeb N. Salem, Andrew S. Levey, Hocine Tighiouart, John L. Griffith |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Inflammation 030204 cardiovascular system & hematology Fibrinogen Gastroenterology Leukocyte Count 03 medical and health sciences 0302 clinical medicine cardiovascular disease Risk Factors White blood cell Internal medicine medicine Humans Risk factor Adverse effect Serum Albumin biology business.industry Hazard ratio C-reactive protein Middle Aged medicine.disease 3. Good health C-Reactive Protein medicine.anatomical_structure Cardiovascular Diseases Nephrology Chronic Disease Immunology biology.protein Female Kidney Diseases medicine.symptom business chronic kidney disease Biomarkers white blood cell count Kidney disease medicine.drug |
| Zdroj: | Kidney International. 73:1406-1412 |
| ISSN: | 0085-2538 |
| Popis: | Inflammation and chronic kidney disease predict cardiovascular events. Here we evaluated markers of inflammation including fibrinogen, albumin and white blood cell count in individuals with and without stages 3–4 chronic kidney disease to assess inflammation as a risk factor for adverse events, the synergy between inflammation and chronic kidney disease, and the prognostic ability of these inflammatory markers relative to that of C-reactive protein. Using Atherosclerosis Risk in Communities and Cardiovascular Health Study data, inflammation was defined by worst quartile of at least 2 of these 3 markers. In Cox regression models, inflammation was assessed as a risk factor for a composite of cardiac events, stroke and mortality as well as components of this composite. Among 20 413 patients, inflammation was identified in 3594 and chronic kidney disease in 1649. In multivariable analyses, both inflammation and chronic kidney disease predicted all outcomes, but their interaction was non-significant. In 5597 patients with C-reactive protein levels, inflammation and elevated C-reactive protein had similar hazard ratios. When focusing only on individuals with the worst quartile of white cell count and albumin, results remained consistent. |
| Databáze: | OpenAIRE |
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