Digital Video Laryngoscopy and Flexible Endoscopic Biopsies as an Alternative Diagnostic Workup in Laryngopharyngeal Cancer: A Prospective Clinical Study

Autor: Piet J. Slootweg, Robert P. Takes, Henri A. M. Marres, Henrieke W. Schutte, Frank J. A. van den Hoogen, Jimmie Honings, Marianne J P A Arts, Guido B. van den Broek
Rok vydání: 2018
Předmět:
Image-Guided Biopsy
Male
medicine.medical_specialty
Laryngoscopy
Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]
Laryngoscopes
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Predictive Value of Tests
Biopsy
Carcinoma
Medicine
Humans
Local anesthesia
Prospective Studies
030223 otorhinolaryngology
Laryngeal Neoplasms
Aged
Laryngopharyngeal cancer
medicine.diagnostic_test
business.industry
Digital video
Pharyngeal Neoplasms
General Medicine
medicine.disease
Otorhinolaryngology
Ambulatory Surgical Procedures
030220 oncology & carcinogenesis
Prospective clinical study
Feasibility Studies
Female
Radiology
business
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Anesthesia
Local
Zdroj: Annals of Otology, Rhinology and Laryngology, 127, 11, pp. 770-776
Annals of Otology, Rhinology and Laryngology, 127, 770-776
ISSN: 1943-572X
0003-4894
Popis: Objectives: An office-based workup strategy for patients with laryngopharyngeal lesions suspicious for carcinoma is analyzed. The feasibility of office-based transnasal flexible endoscopic biopsies under local anesthesia and the impact on the diagnostic workup are evaluated. Methods: This study is a prospective analysis of patients with laryngeal, oropharyngeal, and hypopharyngeal lesions suspicious for carcinoma. One hundred eighty-eight participants were divided into 2 groups. The first group underwent an office-based biopsy procedure under local anesthesia using a flexible digital video laryngoscope with instrument channel (n = 53), and the second group underwent a biopsy procedure under general anesthesia using rigid laryngopharyngoscopy (n = 135). Results: Office-based flexible endoscopic biopsies were tolerated well, and there were no complications. These biopsies were 92.5% successful in acquiring a definitive diagnosis. Costs were reduced. Diagnostic workup time and time until start of therapy were reduced to 2 days and 27 days, respectively. Conclusion: Office-based biopsy under local anesthesia using flexible digital video laryngoscopy is safe, cost-effective, and successful in providing a histopathological diagnosis. It reduces the diagnostic workup time significantly in patients with laryngeal, oropharyngeal, and hypopharyngeal cancer, while also reducing the necessity to subsequently perform a rigid laryngopharyngoscopy under general anesthesia.
Databáze: OpenAIRE
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